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The half-life of the modified-release preparation is. The half-life of the modified-release preparation is. Patients may respond as early as 2 to 4 weeks after the initiation of therapy, but treatment for up to 12 weeks may be needed before a beneficial effect is experienced. Patients may respond as early as 2 to 4 weeks after the initiation of therapy, but treatment for up to 12 weeks may be needed before a beneficial effect is experienced. Provide different insights into pletal therapy on echemi. Provide different insights into pletal therapy on echemi. PLETAL (PLAY-tal) (cilostazol) (sil-OS-tah-zol) Tablets CONTRAINDICATION Cilostazol and several of its metabolites are inhibitors of phosphodiesterase III. PLETAL (PLAY-tal) (cilostazol) (sil-OS-tah-zol) Tablets CONTRAINDICATION Cilostazol and several of its metabolites are inhibitors of phosphodiesterase III. 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